- Published: October 2024
- Pages: 455
- Tables: 48
- Figures: 21
The global microfluidics market demonstrates exceptional growth potential through 2035, driven by transformative applications across healthcare, pharmaceuticals, and industrial sectors. This sophisticated technology, which manipulates fluids at microscopic scales, continues to revolutionize traditional approaches to diagnostics, drug development, and process control. Medical applications currently dominate market share, with point-of-care diagnostics and pharmaceutical research leading growth, while industrial applications in environmental monitoring, food safety, and process control show substantial expansion potential.
Technological innovations in materials science, manufacturing processes, and digital integration continue to reduce production costs and enhance device functionality, enabling broader market adoption. The integration of artificial intelligence, automation, and advanced sensing capabilities creates new application possibilities and market opportunities. Key market drivers include increasing demand for rapid diagnostic solutions, growing investment in pharmaceutical research, and expanding applications in personalized medicine. As manufacturing processes improve and costs decrease, market adoption accelerates across both traditional and emerging applications in areas such as thermal management.
The Global Microfluidics Market 2025-2035 providing detailed insights into market dynamics, technological innovations, and growth opportunities from 2025 to 2035. Report contents include: The microfluidics market is experiencing transformative growth driven by breakthroughs in point-of-care diagnostics, drug discovery applications, and personalized medicine. Report contents include:
- End-Market Segmentation
- Medical Market:
- In-vitro diagnostics
- Drug discovery and development
- Genomics and proteomics
- Point-of-care testing
- Personalized medicine applications
- Organ-on-chip platforms
- Industrial Market:
- Environmental monitoring
- Food and beverage testing
- Oil and gas analysis
- Electronic cooling solutions
- Process control applications
- Quality assurance systems
- Consumer Market:
- Inkjet printing technologies
- Consumer diagnostics
- Wearable devices
- Personal care applications
- Medical Market:
- Developments across materials, manufacturing processes, and integration technologies:
- Advanced polymer technologies
- PDMS alternatives
- Glass and silicon innovations
- Paper-based platforms
- Hybrid materials development
- 3D printing applications
- Injection molding innovations
- Hot embossing techniques
- Wafer-level packaging
- Integration technologies
- Emerging Technologies:
- AI and machine learning integration
- Biosensor developments
- Digital microfluidics
- Paper-based systems
- Organ-on-chip platforms
- Applications and Market Opportunities
- Diagnostics:
- Infectious disease testing
- Oncology applications
- Cardiovascular diagnostics
- Neurological testing
- Genetic screening
- Pharmaceutical Research:
- Drug screening platforms
- Genomics applications
- Proteomics research
- Cell analysis systems
- High-throughput screening
- Environmental and Industrial:
- Water quality analysis
- Food safety testing
- Industrial process control
- Environmental monitoring
- Agricultural applications
- Diagnostics:
- Market Drivers and Challenges
- Regulatory Landscape
- Detailed profiles of 210+ companies including 3M, 10X Genomics, Abbott, AbCellera, Accelix, Achira Labs, AGC, Agilent Technologies, AgPlus Diagnostics, Akonni Biosystems, ALiA Biotech, Aline inc, Allozymes, Alveo, Amberstone Biosciences Inc., Ande Corporation, Arrayit Corporation, Astraveus, Atomica, Atrandi Biosciences, AxBio, Baebies, Bartels Mikrotechnik, Becton Dickinson, BforCure, BGI, Bi.Flow Systems GmbH, Binx Health, Biocartis, Biomensio, bioMérieux, Bionano Genomics, Bioneer, Bio-Rad, BioSurfit, Biotechne, Boehringer Ingelheim, Bosch, Bruker Cellular Analysis, CapitalBiotech Corporation, Capsum, Cellbox Labs, Cellares, CellFE, Cellix Ltd., Charles River Laboratories, ClexBio, CN Bio, Cytovale, Danaher Corporation, Deepcell, Dermagnostix, DiaSorin Molecular, DNA electronics (DNAe), DNA Nudge, Dolomite Microfluidics, Eden Microfluidics, Element Biosciences, Elveflow, Emulate Bio, ENPLAS, Epicore Biosystems, Epigem, Evonetix, FEMTOprint, FinalSpark, Finnadvance, FLEXOMICS LLC, Fluigent, Fluxergy, Genalyte, GenSpeed Biotech GmbH, Hesperos Inc., Hicomp Microtech, Hochuen Medical, IDEX Health & Science, iLine Microsystems, Illumina, Imec, iMiGiNE, IMT AG, Inflammatix, Inorevia, Integra Biosciences, Invetech, InziGn Pte Ltd., Klearia, Kloé, Kypha, LightDeck, LioniX, LuminUltra Technologies, Lunaphore Technologies, Medimate, Mekonos, MeMed BV, Memo Therapeutics AG, Menarini Silicon Biosystems, Mesa labs, MGI Tech, MiCo BioMed USA, Microcaps AG, Microfluidic ChipShop, Micron Biomedical, Micronit, MicrofluidiX, Micropoint Technologies, microTEC, miDiagnostics, Miltenyi Biotec, Mimetas, Minos Biosciences, Mission Bio, Molbio Diagnostics, MZP tech, Nabsys, NanoCellect, NanoDx, NanoEntek, Nanomix, NanoPass, NanoScribe, Netri, Nicoya, Nortis, Nuclera, Nutcracker Therapeutics, Okomera, Ondavia, Opgen Group, OPKO, Optolane Technologies, Orange Biomed, Osler Diagnostics, Oxford Nanopore Technologies, Pacific Biosciences, Paragraf, Parallel Fluidics, Pattern Bioscience, Perkinelmer, Philips Engineering Solutions, Phillips Medisize, PixCell Medical, Potomac Photonics (Goodfellow), Precision Nanosystems, Qiagen, Qorvo Biotechnologies, Quanterix, QuantuMDx, Quantum-Si, QuidelOrtho, Qurin Diagnostics, Rab-Microfluidics and more....
- Future Outlook Analysis of emerging opportunities
- Supply Chain Analysis:
- Raw materials suppliers
- Component manufacturers
- Device integrators
- End-user markets
- Distribution channels
- Market Opportunities
1 EXECUTIVE SUMMARY 16
- 1.1 Market Size 23
- 1.2 Key Market Drivers and Challenges 24
- 1.3 Emerging Trends and Technologies 24
- 1.4 Market Drivers 26
- 1.4.1 Advancements in Point-of-Care Diagnostics 26
- 1.4.1.1 Rapid Testing for Infectious Diseases 26
- 1.4.1.2 Chronic Disease Management 27
- 1.4.1.3 Decentralized Healthcare Trends 28
- 1.4.2 Increasing Demand for Personalized Medicine 29
- 1.4.2.1 Genomics and Proteomics Applications 29
- 1.4.2.2 Targeted Drug Delivery Systems 30
- 1.4.2.3 Companion Diagnostics 30
- 1.4.3 Growth in Drug Discovery and Life Sciences Research 31
- 1.4.3.1 High-Throughput Screening 31
- 1.4.3.2 Organ-on-a-Chip Models 33
- 1.4.3.3 Single-Cell Analysis 34
- 1.4.4 Emerging Applications in Industrial and Environmental Monitoring 35
- 1.4.4.1 Water Quality Testing 35
- 1.4.4.2 Food Safety Analysis 36
- 1.4.4.3 Industrial Process Control 37
- 1.4.1 Advancements in Point-of-Care Diagnostics 26
- 1.5 Market Restraints and Challenges 38
- 1.5.1 High Initial Costs and Complexities in Manufacturing 38
- 1.5.2 Standardization and Regulatory Challenges 39
- 1.5.3 Limited Awareness and Adoption in Emerging Markets 40
- 1.5.4 Scaling Up Production While Maintaining Quality 41
- 1.5.5 Competing Technologies and Alternative Solutions 42
- 1.6 Market Opportunities 43
- 1.6.1 Integration of AI and IoT in Microfluidic Devices 43
- 1.6.2 Expansion in Emerging Economies 44
- 1.6.3 Novel Applications in Organ-on-a-Chip and 3D Cell Culture 45
- 1.7 Competitive Landscape Overview 46
2 INTRODUCTION 48
- 2.1 Types of Microfluidic Technologies 48
- 2.1.1 Continuous-flow Microfluidics 50
- 2.1.2 Droplet-based Microfluidics 51
- 2.1.3 Digital Microfluidics 52
- 2.1.4 Paper-based Microfluidics 53
3 GLOBAL MARKET SIZE AND FORECAST (2025-2035) 55
- 3.1 Overall Market Size and Growth Rate 55
- 3.1.1 Historical Market Size (2020-2024) 55
- 3.1.2 Forecast Market Size (2025-2035) 56
- 3.2 Market Segmentation by End-Use Markets 58
- 3.2.1 Consumer Market 59
- 3.2.1.1 Inkjet Printing 61
- 3.2.1.2 Consumer Diagnostics 62
- 3.2.1.3 Wearable Devices 62
- 3.2.2 Industrial Market 64
- 3.2.2.1 Environmental Monitoring 65
- 3.2.2.2 Food and Beverage Testing 66
- 3.2.2.3 Oil and Gas Analysis 68
- 3.2.2.4 Electronic Cooling Solutions 69
- 3.2.3 Medical Market 70
- 3.2.3.1 In-Vitro Diagnostics 71
- 3.2.3.2 Drug Discovery and Development 72
- 3.2.3.3 Genomics and Proteomics 73
- 3.2.3.4 Point-of-Care Testing 75
- 3.2.1 Consumer Market 59
- 3.3 Regional Market Analysis 76
- 3.3.1 North America 77
- 3.3.2 Europe 78
- 3.3.3 Asia-Pacific 80
- 3.3.4 Rest of the World 81
4 MARKETS AND APPLICATIONS 82
- 4.1 Diagnostics 83
- 4.1.1 Infectious Diseases 84
- 4.1.2 Oncology 85
- 4.1.3 Cardiology 86
- 4.1.4 Others 87
- 4.2 Pharmaceutical and Life Science Research 87
- 4.2.1 Drug Screening 89
- 4.2.2 Genomics 89
- 4.2.3 Proteomics 90
- 4.2.4 Cell Analysis 92
- 4.3 Inkjet Printing 92
- 4.3.1 Consumer Printing 92
- 4.3.2 Industrial Printing 92
- 4.3.3 3D Printing 94
- 4.4 Environmental and Food Safety Testing 94
- 4.4.1 Water Quality Analysis 96
- 4.4.2 Food Contaminant Detection 98
- 4.4.3 Soil Analysis 99
- 4.5 Others (e.g., Cosmetics, Agriculture) 101
- 4.6 Module Types 103
- 4.6.1 Microfluidic Chips 104
- 4.6.2 Pumps and Valves 105
- 4.6.3 Sensors and Detectors 106
- 4.6.4 Microfluidic Cartridges 109
- 4.6.5 Others 111
- 4.7 Materials 111
- 4.7.1 Polymer 113
- 4.7.1.1 Thermoplastics (PMMA, COC, PS) 114
- 4.7.1.2 Thermosets 115
- 4.7.1.3 Elastomers 117
- 4.7.2 PDMS (Polydimethylsiloxane) 118
- 4.7.3 Glass Wafers 119
- 4.7.4 Silicon Wafers 121
- 4.7.5 Paper and Other Materials 122
- 4.7.5.1 Multiplexed Analysis Platforms 126
- 4.7.5.2 Integration with IoT for Real-time Monitoring 127
- 4.7.1 Polymer 113
5 MARKET TRENDS 128
- 5.1 Consumer Market Trends 128
- 5.1.1 Evolution of Inkjet Printing Technologies 128
- 5.1.1.1 Continuous Inkjet (CIJ) vs. Drop-on-Demand (DOD) 128
- 5.1.1.2 Advancements in Printhead Technology 129
- 5.1.1.3 Eco-friendly Inks and Sustainability Trends 130
- 5.1.1 Evolution of Inkjet Printing Technologies 128
- 5.1.2 Emerging Consumer Diagnostics and Wellness Devices 132
- 5.1.2.1 At-home Testing Kits 132
- 5.1.2.2 Wearable Microfluidic Devices 133
- 5.1.2.3 Personalized Nutrition and Hydration Monitoring 134
- 5.2 Industrial Market Trends 135
- 5.2.1 Advancements in Environmental and Food Safety Testing 135
- 5.2.1.1 Rapid On-site Detection Systems 136
- 5.2.1.2 Multiplexed Analysis Platforms 137
- 5.2.1.3 Integration with IoT for Real-time Monitoring 138
- 5.2.2 Applications in Oil Testing and Agriculture 139
- 5.2.2.1 In-situ Oil Analysis 139
- 5.2.2.2 Precision Agriculture and Crop Management 140
- 5.2.2.3 Soil Health Monitoring 140
- 5.2.3 Electronic Cooling Solutions 141
- 5.2.3.1 Microfluidic Cooling for High-Performance Computing 142
- 5.2.3.2 Innovations in Data Center Cooling 143
- 5.2.3.3 Challenges and Opportunities in Chip-level Cooling 144
- 5.2.1 Advancements in Environmental and Food Safety Testing 135
- 5.3 Medical Market Trends 145
- 5.3.1 Point-of-Care Diagnostics Evolution 145
- 5.3.1.1 Smartphone-integrated Diagnostics 147
- 5.3.1.2 Multiplexed POC Platforms 148
- 5.3.1.3 Emerging Biomarkers and Test Types 149
- 5.3.2 Microfluidics in Drug Discovery and Development 150
- 5.3.2.1 High-Throughput Screening Platforms 151
- 5.3.2.2 Organ-on-a-Chip for Drug Testing 152
- 5.3.2.3 Personalized Drug Efficacy Testing 154
- 5.3.3 Next-Generation Sequencing Advancements 154
- 5.3.3.1 Microfluidic-based Library Preparation 155
- 5.3.3.2 Single-cell Sequencing Platforms 155
- 5.3.3.3 Long-read Sequencing Technologies 157
- 5.3.4 Microphysiological Systems and Organ-on-a-Chip 158
- 5.3.4.1 Multi-organ Systems 159
- 5.3.4.2 Disease Modeling 161
- 5.3.4.3 Personalized Medicine Applications 161
- 5.3.5 Cell Analysis and Therapy Applications 162
- 5.3.5.1 Circulating Tumor Cell (CTC) Analysis 163
- 5.3.5.2 CAR-T Cell Manufacturing 165
- 5.3.5.3 Stem Cell Research and Therapy 166
- 5.3.1 Point-of-Care Diagnostics Evolution 145
6 SUPPLY CHAIN ANALYSIS 167
- 6.1 Raw Materials and Components Suppliers 168
- 6.2 Microfluidic Chip Manufacturers 170
- 6.3 Module and Device Integrators 172
- 6.4 End-Users 174
7 TECHNOLOGY TRENDS AND INNOVATIONS 176
- 7.1 Development of Biosensors 176
- 7.1.1 Photonic Sensors for Cell Therapy 176
- 7.1.1.1 Working Principles 177
- 7.1.1.2 Applications in Cell Sorting and Analysis 177
- 7.1.1.3 Challenges and Future Prospects 178
- 7.1.2 Silicon-Based Biosensors for Point-of-Care Diagnostics 179
- 7.1.2.1 CMOS-Integrated Biosensors 179
- 7.1.2.2 Label-free Detection Methods 181
- 7.1.2.3 Multiplexed Sensing Platforms 183
- 7.1.1 Photonic Sensors for Cell Therapy 176
- 7.2 Materials Innovations 184
- 7.2.1 Advancements in Polymer Technologies 184
- 7.2.1.1 High-Performance Thermoplastics 185
- 7.2.1.2 Biodegradable Polymers 188
- 7.2.1.3 Surface Modification Techniques 189
- 7.2.2 PDMS Alternatives and Hybrid Materials 190
- 7.2.2.1 Thermoplastic Elastomers 190
- 7.2.2.2 Fluoropolymers 191
- 7.2.2.3 Glass-Polymer Hybrids 192
- 7.2.3 Glass and Silicon Wafer Innovations 193
- 7.2.3.1 Ultra-thin Glass Substrates 193
- 7.2.3.2 3D-Structured Silicon 194
- 7.2.3.3 Nanoporous Materials 195
- 7.2.1 Advancements in Polymer Technologies 184
- 7.3 Manufacturing Trends 196
- 7.3.1 Polymer Manufacturing Advancements 197
- 7.3.1.1 Injection Molding Innovations 198
- 7.3.1.2 Hot Embossing Techniques 200
- 7.3.1.3 3D Printing of Microfluidic Devices 201
- 7.3.2 Silicon and Glass Manufacturing Techniques 202
- 7.3.2.1 Deep Reactive Ion Etching (DRIE) 203
- 7.3.2.2 Wafer-level Packaging 204
- 7.3.2.3 Through-Silicon Vias (TSVs) 205
- 7.3.3 Backend Processes and Integration 207
- 7.3.3.1 Bonding Technologies 208
- 7.3.3.2 Surface Treatments and Coatings 209
- 7.3.3.3 Integration of Electronics and Microfluidics 211
- 7.3.1 Polymer Manufacturing Advancements 197
- 7.4 Emerging Technologies 212
- 7.4.1 AI and Machine Learning Integration 212
- 7.4.1.1 Automated Design of Microfluidic Circuits 213
- 7.4.1.2 Predictive Maintenance of Microfluidic Systems 214
- 7.4.1.3 Data Analysis and Interpretation 215
- 7.4.2 3D Printing in Microfluidics 216
- 7.4.2.1 Stereolithography (SLA) for Microfluidics 218
- 7.4.2.2 Multi-material 3D Printing 219
- 7.4.2.3 Bioprinting of Tissue Constructs 220
- 7.4.3 Paper-Based Microfluidics 222
- 7.4.3.1 Fabrication Methods 223
- 7.4.3.2 Applications in Low-Resource Settings 224
- 7.4.3.3 Integration with Smartphones for Readout 225
- 7.4.1 AI and Machine Learning Integration 212
8 REGULATORY LANDSCAPE 226
- 8.1 Overview of Regulatory Framework for Microfluidic Devices 226
- 8.2 FDA Regulations (USA) 228
- 8.2.1 Classification of Microfluidic Devices 230
- 8.2.2 Premarket Approval (PMA) Process 232
- 8.2.3 510(k) Clearance Process 232
- 8.3 CE Marking (Europe) 233
- 8.3.1 Medical Device Regulation (MDR) 233
- 8.3.2 In Vitro Diagnostic Regulation (IVDR) 234
- 8.3.3 Conformity Assessment Procedures 235
- 8.4 NMPA Regulations (China) 237
- 8.4.1 Registration Process for Medical Devices 238
- 8.4.2 Clinical Trial Requirements 240
- 8.4.3 Manufacturing and Quality Control Standards 241
9 FUTURE OUTLOOK AND MARKET OPPORTUNITIES 242
- 9.1 Emerging Applications and Use Cases 242
- 9.1.1 Microfluidics in Space Research 242
- 9.1.2 Microbiome Analysis and Engineering 243
- 9.2 Neurotechnology 244
- 9.2.1 Neurotechnology and Brain-on-a-Chip 244
- 9.2.2 Synthetic Biology and Biofabrication 244
- 9.2.3 Advanced Materials Testing and Development 245
- 9.3 Potential Impact of Generative AI on Microfluidics 246
- 9.3.1 AI-Driven Design Optimization 246
- 9.3.2 Predictive Modeling of Fluid Dynamics 247
- 9.3.3 Automated Data Analysis and Interpretation 247
- 9.4 Microfluidics in Precision Medicine and Personalized Healthcare 248
- 9.4.1 Liquid Biopsy and Circulating Biomarkers 248
- 9.4.2 Personalized Drug Screening 249
- 9.4.3 Microfluidic Devices for Continuous Health Monitoring 249
- 9.5 Opportunities in Developing Economies 250
- 9.5.1 Point-of-Care Diagnostics for Resource-Limited Settings 251
- 9.5.2 Affordable Microfluidic Solutions for Agriculture 252
- 9.5.3 Environmental Monitoring in Rapidly Industrializing Regions 252
10 COMPANY PROFILES 254 (210 company profiles)
11 APPENDICES 445
- 11.1 Glossary of Terms 445
- 11.2 List of Abbreviations 446
- 11.3 Research Methodology 448
12 REFERENCES 449
List of Tables
- Table 1. Key Market Drivers. 25
- Table 2. Emerging Trends and Technologies. 26
- Table 3. Decentralized Healthcare Trends. 29
- Table 4. Genomics and Proteomics Applications. 30
- Table 5. Organ-on-a-Chip Models. 34
- Table 6. Emerging Opportunities in Microfluidics Market. 36
- Table 7. Market Restraints and Challenges. 39
- Table 8. Competing Technologies and Alternative Solutions. 43
- Table 9. Types of Microfluidic Technologies and Their Applications. 49
- Table 10. Comparison of Microfluidics with Alternative Technologies. 54
- Table 11. Global Microfluidics Market Size by End-Market, 2020-2024 ($B). 56
- Table 12. Global Microfluidics Market Size by End-Market, 2025-2035 ($B). 57
- Table 13. Market Share by End-Market Segment, 2025-2035 ($B). 59
- Table 14. Consumer Market Size by Application, 2025-2035 ($B). 60
- Table 15. Industrial Market Size by Application, 2025-2035 ($B)... 65
- Table 16. Medical Market Size by Application, 2025-2035 ($B). 71
- Table 17. Regional Market Size, 2025-2035 ($B). 77
- Table 18. Diagnostics Market by Disease Area, 2025-2035 ($B). 84
- Table 19. Pharmaceutical and Life Science Research Market Trends,. 88
- Table 20. Inkjet Printing Market by Type, 2025-2035 ($B). 93
- Table 21. Environmental and Food Safety Testing Market, 2025-2035 ($B). 95
- Table 22. Market Size by Module Type, 2025-2035 ($B). 104
- Table 23. Market Share by Material Type, 2025 vs 2035. 112
- Table 24. Advancements in Printhead Technology. 130
- Table 25. Emerging Biomarkers and Test Types 150
- Table 26. Comparison of Microfluidic Platforms for Drug Discovery. 151
- Table 27. Single-cell Sequencing Platforms. 156
- Table 28. Raw Materials and Components Suppliers. 169
- Table 29. Microfluidic Chip Manufacturers. 171
- Table 30. Module and Device Integrators. 173
- Table 31. Comparison of Photonic Sensors for Cell Therapy Applications. 177
- Table 32. Applications in Cell Sorting and Analysis. 178
- Table 33. CMOS-Integrated Biosensors. 180
- Table 34. Label-free Detection Methods. 182
- Table 35. Multiplexed Sensing Platforms. 184
- Table 36. Advanced Polymer Materials for Microfluidics, Properties and Applications. 185
- Table 37. High-Performance Thermoplastics. 186
- Table 38. Biodegradable Polymers. 189
- Table 39. Surface Modification Techniques. 190
- Table 40. Polymer Manufacturing Techniques Comparison. 198
- Table 41. Silicon and Glass Manufacturing Techniques, Pros and Cons. 203
- Table 42. Backend Processes and Integration Trends. 208
- Table 43. AI and ML Applications in Microfluidics,. 213
- Table 44. Paper-Based Microfluidics Fabrication Methods. 224
- Table 45. Global Regulatory Framework for Microfluidic Devices. 227
- Table 46. FDA Classification of Microfluidic Devices. 231
- Table 47. Glossary of terms. 446
- Table 48. List of Abbreviations. 447
List of Figures
- Figure 1. Global Microfluidics Market Size and Growth Rate, 2025-2035. 24
- Figure 2. Point-of-Care Diagnostics Market Growth, 2025-2035. 27
- Figure 3. Microfluidics Market Map. 48
- Figure 4. A schematic design of a microfluidic flow. 49
- Figure 5. Digital Microfluidics. 53
- Figure 6. Global Microfluidics Market Size by End-Market, 2020-2024 ($B). 57
- Figure 7. Global Microfluidics Market Size by End-Market, 2025-2035 ($B). 58
- Figure 8. Market Share by End-Market Segment, 2025-2035 ($B). 60
- Figure 9. Consumer Market Size by Application, 2025-2035 ($B).. 61
- Figure 10. Industrial Market Size by Application, 2025-2035 ($B).. 66
- Figure 11. Medical Market Size by Application, 2025-2035 ($B). 72
- Figure 12. Regional Market Size, 2025-2035 ($B).. 78
- Figure 13. Diagnostics Market by Disease Area, 2025-2035 ($B). 85
- Figure 14. Market Size by Module Type, 2025-2035 ($B). 105
- Figure 15. Overview of the Microfluidics Supply Chain. 168
- Figure 16. Bioprocessor with eight electrodes attached to four arrays each housing a cluster of brain cells. 314
- Figure 17. GridION. 370
- Figure 18. QuantumX MX879B. 384
- Figure 19. Qurin Biosensor. 387
- Figure 20. Oleum Oracle®. 388
- Figure 21. Apollo. 391
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