Nanotechnology and nanomaterials solutions for COVID-19

Diagnostic testing, antiviral and antimicrobial coatings and surfaces, air-borne filtration, facemasks, PPE, drug delivery and therapeutics

Published May 25 2020, 273 pages, 41 tables, 51 figures

Nanotechnology and nanomaterials can significantly address the many clinical and public healthcare challenges that have arisen from the coronavirus pandemic. This analysis examines in detail how nanotechnology and nanomaterials can help in the fight against this pandemic disease, and ongoing mitigation strategies. Nano-based products are currently being developed and deployed for the containment, diagnosis, and treatment of Covid-19.

Nanotechnology and nanomaterials promise:

Improved and virus disabling air filtration.
Low-cost, scalable detection methods for the detection of viral particles
Enhanced personal protection equipment (PPE) including facemasks.
New antiviral vaccine and drug delivery platforms.
New therapeutic solutions.

Report contents include:

Market analysis of nano-based diagnostic tests for COVID-19 including nanosensors incorporating gold nanoparticles, iron oxide nanoparticles, graphene, quantum dots, carbon quantum dots and carbon nanotubes. Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include Abbott Laboratories, Cardea, Ferrotec (USA) Corporation, E25Bio, Grolltex, Inc., Luminex Corporation etc.
Market analysis of antiviral and antimicrobial nanocoatings for surfaces including fabric (mask, gloves, doctor coats, curtains, bed sheet), metal (lifts, doors handle, nobs, railings, public transport), wood (furniture, floors and partition panels), concrete (hospitals, clinics and isolation wards) and plastics (switches, kitchen and home appliances).
Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include Advanced Materials-JTJ s.r.o., Bio-Fence, Bio-Gate AG, Covalon Technologies Ltd., EnvisionSQ, GrapheneCA, Integricote, Nano Came Co. Ltd., NanoTouch Materials, LLC, NitroPep and many more.
Market analysis of air-borne virus filtration including photocatalytic Nano-TiO2 filters, nanofiber filers, nanosilver, nanocellulose, graphene and carbon nanotube filtration. Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include G6 Materials, Daicel FineChem Ltd., NANOVIA s.r.o., Toray Industries, Inc., Tortech Nano Fibers etc.
Market analysis of nano-based facemask and other PPE products. Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include planarTECH LLC, RESPILON Group s. r. o., SITA, Sonovia Ltd. etc.
Nanotherapies and drug delivery vehicles currently being produced and clinical trials of vaccines for COVID-19. Market revenues adjusted to pandemic outcomes. In-depth company profiles. In-depth company profiles. Companies profiled include Arcturus Therapeutics, Inc., Arbutus Biopharma, BlueWillow Biologics, Elastrin Therapeutics Inc., EnGeneIC Ltd. etc.
Key scientific breakthroughs and developments that are underway right now.

Download Table of contents (PDF)

1 RESEARCH SCOPE AND METHODOLOGY 20

1.1 Report scope 20
1.2 Research methodology 20

2 INTRODUCTION 22

3 DIAGNOSTIC TESTING 24

3.1 Nanotechnology and nanomaterials solutions 24
- 3.1.1 Current Diagnostic Tests for COVID-19 24
- 3.1.2 Emerging Diagnostic Tests for COVID-19 25
- 3.1.3 Nanosensors/nanoparticles 28
- 3.1.4 Carbon nanomaterials for diagnostic testing 31
3.2 Market revenues 34
- 3.2.1 Market estimates adjusted to pandemic demand, forecast to 2025 34
3.3 Companies 36 (41 COMPANY PROFILES)
3.4 Academic research 62

4 ANTIVIRAL AND ANTIMICROBIAL COATINGS AND SURFACES 64

4.1 Nanotechnology and nanomaterials solutions 64
- 4.1.1 Nanocoatings 67
- 4.1.2 Applications 70
- 4.1.3 Anti-viral nanoparticles and nanocoatings 72
  - 4.1.3.1 Reusable Personal Protective Equipment (PPE) 73
  - 4.1.3.2 Wipe on coatings 74
- 4.1.4 Graphene-based coatings 76
  - 4.1.4.1 Properties 76
  - 4.1.4.2 Graphene oxide 78
  - 4.1.4.3 Reduced graphene oxide (rGO) 79
  - 4.1.4.4 Markets and applications 80
- 4.1.5 Silicon dioxide/silica nanoparticles (Nano-SiO2) -based coatings 81
  - 4.1.5.1 Properties 81
  - 4.1.5.2 Antimicrobial and antiviral activity 82
  - 4.1.5.3 Easy-clean and dirt repellent 83
- 4.1.6 Nanosilver-based coatings 84
  - 4.1.6.1 Properties 84
  - 4.1.6.2 Antimicrobial and antiviral activity 84
  - 4.1.6.3 Markets and applications 85
  - 4.1.6.4 Commercial activity 86
- 4.1.7 Titanium dioxide nanoparticle-based coatings 87
  - 4.1.7.1 Properties 87
  - 4.1.7.2 Exterior and construction glass coatings 89
  - 4.1.7.3 Outdoor air pollution 91
  - 4.1.7.4 Interior coatings 91
  - 4.1.7.5 Medical facilities 92
  - 4.1.7.6 Wastewater Treatment 92
  - 4.1.7.7 Antimicrobial coating indoor light activation 92
- 4.1.8 Zinc oxide nanoparticle-based coatings 93
  - 4.1.8.1 Properties 93
  - 4.1.8.2 Antimicrobial activity 94
- 4.1.9 Nanocellullose (cellulose nanofibers and cellulose nanocrystals)-based coatings 96
  - 4.1.9.1 Properties 96
  - 4.1.9.2 Antimicrobial activity 97
- 4.1.10 Carbon nanotube-based coatings 98
  - 4.1.10.1 Properties 98
  - 4.1.10.2 Antimicrobial activity 98
- 4.1.11 Fullerene-based coatings 99
  - 4.1.11.1 Properties 99
  - 4.1.11.2 Antimicrobial activity 99
- 4.1.12 Chitosan nanoparticle-based coatings 100
  - 4.1.12.1 Properties 100
  - 4.1.12.2 Wound dressings 102
  - 4.1.12.3 Packaging coatings and films 102
  - 4.1.12.4 Food storage 102
- 4.1.13 Copper nanoparticle-based coatings 103
  - 4.1.13.1 Properties 103
  - 4.1.13.2 Application in antimicrobial nanocoatings 103
4.2 Market revenues 103
- 4.2.1 Market revenues adjusted to pandemic demand, forecast to 2030 103
4.3 Companies 108 (112 COMPANY PROFILES)
4.4 Academic research 189

5 AIR-BORNE VIRUS FILTRATION 191

5.1 Nanotechnology and nanomaterials solutions 191
5.2 Market revenues 197
- 5.2.1 Market estimates adjusted to pandemic demand, forecast to 2025 197
5.3 Companies 199 (31 COMPANY PROFILES)
5.4 Academic research 222

6 FACEMASKS AND OTHER PPE 224

6.1 Nanotechnology and nanomaterials solutions 224
6.2 Market revenues 225
- 6.2.1 Market estimates adjusted to pandemic demand, forecast to 2025 225
6.3 Companies 227 (10 COMPANY PROFILES)
6.4 Academic research 233

7 DRUG DELIVERY AND THERAPEUTICS 234

7.1 Nanotechnology and nanomaterials solutions 234
- 7.1.1 Products 236
- 7.1.2 Nanocarriers 239
- 7.1.3 Nanovaccines 242
7.2 Market revenues 244
- 7.2.1 Market estimates adjusted to pandemic demand, forecast to 2025 244
7.3 Companies 245 (45 COMPANY PROFILES)
7.4 Academic research 269

8 REFERENCES 270

Tables

Table 1. Current Diagnostic Tests for COVID-19. 24
Table 2. Development phases of diagnostic tests. 26
Table 3. Emerging Diagnostic Tests for COVID-19. 26
Table 4. Nanoparticles for diagnostic testing-Types of nanoparticles, properties and application. 28
Table 5. Gold nanoparticle reagent suppliers list. 30
Table 6. Carbon nanomaterials for diagnostic testing-types, properties and applications. 33
Table 7. Global revenues for nanotech-based diagnostics and testing, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates. 34
Table 8. Academic research in nano-based COVID-19 diagnostics and testing. 62
Table 9: Anti-microbial and antiviral nanocoatings-Nanomaterials used, principles, properties and applications 65
Table 10. Nanomaterials utilized in antimicrobial and antiviral nanocoatings coatings-benefits and applications. 68
Table 11: Properties of nanocoatings. 69
Table 12: Antimicrobial and antiviral nanocoatings markets and applications. 71
Table 13: Nanomaterials used in nanocoatings and applications. 75
Table 14: Graphene properties relevant to application in coatings. 77
Table 15. Bactericidal characters of graphene-based materials. 79
Table 16. Markets and applications for antimicrobial and antiviral nanocoatings graphene nanocoatings. 80
Table 17. Markets and applications for antimicrobial and antiviral nanosilver coatings. 85
Table 18. Commercial activity in antimicrobial nanosilver nanocoatings. 87
Table 19. Antibacterial effects of ZnO NPs in different bacterial species. 95
Table 20. Types of carbon-based nanoparticles as antimicrobial agent, their mechanisms of action and characteristics. 100
Table 21. Mechanism of chitosan antimicrobial action. 101
Table 22. Global revenues for antimicrobial and antiviral nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates. 104
Table 23. Global revenues for Anti-fouling & easy clean nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates. 105
Table 24. Global revenues for self-cleaning (bionic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates. 106
Table 25. Global revenues for self-cleaning (photocatalytic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates. 107
Table 26. Antimicrobial, antiviral and antifungal nanocoatings research in academia. 189
Table 27. Cellulose nanofibers (CNF) membranes. 191
Table 28: Comparison of CNT membranes with other membrane technologies 192
Table 29. Nanomaterials in air-borne virus filtration-properties and applications. 194
Table 30. Global revenues for nanotech-based air-borne virus filtration, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates. 197
Table 31: Oji Holdings CNF products. 217
Table 32. Academic research in nano-based air-borne virus filtration. 222
Table 33. Nanomaterials in facemasks and other PPE-properties and applications. 224
Table 34. Global revenues for nanotech-based facemasks and PPE, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates. 225
Table 35. Academic research in nano-based facemasks and other PPE. 233
Table 36. Applications in drug delivery and therapeutics, by nanomaterials type-properties and applications. 234
Table 37. Nanotechnology drug products. 236
Table 38. List of antigens delivered by using different nanocarriers. 241
Table 39. Nanoparticle-based vaccines. 243
Table 40. Global revenues for nano-based drug delivery and therapeutics, 2019-2030, billion US$, adjusted for COVID-19 related demand, conservative and high estimates. 244
Table 41. Academic research in nano-based drug delivery and therapeutics to address COVD-19. 269

Figures

Figure 1. Anatomy of COVID-19 Virus. 22
Figure 2. Graphene-based sensors for health monitoring. 32
Figure 3. Schematic of COVID-19 FET sensor incorporating graphene. 33
Figure 4. Global revenues for nanotech-based diagnostics and testing, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates. 35
Figure 5. Printed graphene biosensors. 38
Figure 6. AGILE R100 system. 41
Figure 7. nano-screenMAG particles. 43
Figure 8. GFET sensors. 47
Figure 9. DNA endonuclease-targeted CRISPR trans reporter (DETECTR) system. 50
Figure 10. SGTi-flex COVID-19 IgM/IgG. 60
Figure 11. Schematic of anti-viral coating using nano-actives for inactivation of any adhered virus on the surfaces. 73
Figure 12: Graphair membrane coating. 77
Figure 13: Antimicrobial activity of Graphene oxide (GO). 79
Figure 14. Nano-coated self-cleaning touchscreen. 83
Figure 15: Hydrophobic easy-to-clean coating. 83
Figure 16 Anti-bacterial mechanism of silver nanoparticle coating. 85
Figure 17: Mechanism of photocatalysis on a surface treated with TiO2 nanoparticles. 88
Figure 18: Schematic showing the self-cleaning phenomena on superhydrophilic surface. 88
Figure 19: Titanium dioxide-coated glass (left) and ordinary glass (right). 90
Figure 20: Self-Cleaning mechanism utilizing photooxidation. 90
Figure 21: Schematic of photocatalytic air purifying pavement. 91
Figure 22: Schematic of photocatalytic water purification. 92
Figure 23. Schematic of antibacterial activity of ZnO NPs. 95
Figure 24: Types of nanocellulose. 97
Figure 25. Mechanism of antimicrobial activity of carbon nanotubes. 98
Figure 26: Fullerene schematic. 99
Figure 27. TEM images of Burkholderia seminalis treated with (a, c) buffer (control) and (b, d) 2.0 mg/mL chitosan; (A: additional layer; B: membrane damage). 101
Figure 28. Global revenues for antimicrobial and antiviral nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates. 105
Figure 29. Global revenues for anti-fouling and easy-to-clean nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates 106
Figure 30. Global revenues for self-cleaning (bionic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates 107
Figure 31. Global revenues for self-cleaning (photocatalytic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates 108
Figure 32. Lab tests on DSP coatings. 128
Figure 33. GrapheneCA anti-bacterial and anti-viral coating. 134
Figure 34. Microlyte® Matrix bandage for surgical wounds. 141
Figure 35. Self-cleaning nanocoating applied to face masks. 143
Figure 36. NanoSeptic surfaces. 162
Figure 37. NascNanoTechnology personnel shown applying MEDICOAT to airport luggage carts. 167
Figure 38. Basic principle of photocatalyst TiO2. 194
Figure 39. Schematic of photocatalytic indoor air purification filter. 194
Figure 40. Global revenues for nanotech-based air-borne virus filtration, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates. 198
Figure 41. Multi-layered cross section of CNF-nw. 201
Figure 42: Properties of Asahi Kasei cellulose nanofiber nonwoven fabric. 201
Figure 43: CNF nonwoven fabric. 203
Figure 44: CNF gel. 210
Figure 45. CNF clear sheets. 216
Figure 46. Graphene anti-smog mask. 223
Figure 47. Global revenues for nanotech-based facemasks and PPE, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates. 226
Figure 48. FNM’s nanofiber-based respiratory face mask. 227
Figure 49. ReSpimask® mask. 231
Figure 50. Schematic of different nanoparticles used for intranasal vaccination. 240
Figure 51. Global revenues for nano-based drug delivery and therapeutics, 2019-2030, billion US$, adjusted for COVID-19 related demand, conservative and high estimates. 245

Nanotechnology and nanomaterials solutions for COVID-19

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Diagnostic testing, antiviral and antimicrobial coatings and surfaces, air-borne filtration, facemasks, PPE, drug delivery and therapeutics

Published May 25 2020, 273 pages, 41 tables, 51 figures

1 RESEARCH SCOPE AND METHODOLOGY 20

2 INTRODUCTION 22

3 DIAGNOSTIC TESTING 24

4 ANTIVIRAL AND ANTIMICROBIAL COATINGS AND SURFACES 64

5 AIR-BORNE VIRUS FILTRATION 191

6 FACEMASKS AND OTHER PPE 224

7 DRUG DELIVERY AND THERAPEUTICS 234

8 REFERENCES 270

Tables

Figures

Payment methods: Visa, Mastercard, American Express, Alipay, Paypal.

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